New research indicates that individuals who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain shed pounds far faster than those who halt conventional diet and exercise programs.
Published data in a major medical journal demonstrates that while obese individuals frequently drop substantial amounts of their body weight while using the jabs, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying these drugs must be cognizant of the potential of fast weight regain when the therapy ends," cautioned lead investigator Dr. Susan Jebb.
That rate of recovery implies a return to starting mass within about 18 months.
Analyzing Therapies
The research, which looked at 37 of studies involving over 9,000 of patients, contrasted the effects of the injectable medications with older methods.
Researchers emphasize that individuals who shed pounds through diet and exercise generally see a slower weight regain—perhaps 0.1 kg a month—after stopping.
The Reason for the Fast Regain
Nutrition scientists believe the way of the jabs explains the heightened weight return.
GLP-1 drugs copy a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Artificially providing the hormone levels far above than normal could lead to the body to produce less of its endogenous GLP-1, and may also lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication results in hunger is no longer kept in check, making overeating far more likely."
A Chronic Disease?
Health authorities suggest the injections for people with weight-linked health risks, alongside recommended lifestyle changes.
Professionals argue that, considering the significant potential of relapse, the therapy might need to be long-term.
This opinion is supported by drug manufacturers, who note that the findings "emphasize the chronic character of obesity," akin to managing conditions like high blood pressure.
Patient Experiences
Individuals who have come off the medication report a intense return of cravings.
"It was like a trigger flipping and you're instantly starving," said a patient.
This challenge is exacerbated if patients have not adopted permanent dietary or behavioural changes during treatment.
Growing Use
Figures indicate that a significant number of adults in the UK have tried weight-loss jabs in the last 12 months, with desire remaining high.
- Use is higher among females compared to men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private healthcare rather than the NHS.
Finally, researchers caution that while the jabs are potent tools for weight loss, they are not a permanent fix and lasting health benefits hinges on combined behavioural changes.
